Xeroderma pigmentosum is a definite cause of Huntington's disease‐like syndrome

نویسندگان

  • Hector Garcia‐Moreno
  • Hiva Fassihi
  • Robert P.E. Sarkany
  • Julie Phukan
  • Thomas Warner
  • Alan R. Lehmann
  • Paola Giunti
چکیده

Xeroderma pigmentosum is characterized by cutaneous, ophthalmological, and neurological features. Although it is typical of childhood, late presentations can mimic different neurodegenerative conditions. We report two families presenting as Huntington's disease-like syndromes. The first case (group G) presented with neuropsychiatric features, cognitive decline and chorea. Typical lentigines were only noticed after the neurological disease started. The second case (group B) presented adult-onset chorea and neuropsychiatric symptoms after an aggressive ocular melanoma. Xeroderma pigmentosum can manifest as a Huntington's Disease-like syndrome. Classic dermatological and oncological features have to be investigated in choreic patients with negative genetic tests for Huntington's disease-like phenotypes.

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2018